After what happened in the last episode, Zoey is worried that Mark might find out her secret. On the day of the Kendo tournament that Mark is in, Dren attacks Mark with an Amoeba Predasite. Will Zoey be brave enough to defeat Dren's Predasite and keep Mark from getting killed?
- Because The Main Mew's Muse was not considered an actual episode, there is a significant plot hole caused by the "disappearance".
- The episode title is a pun on the phrase "Time and time again".